There is an ongoing debate in anthropology on the kinds of subject positions activists ascribe to the marginalized actors they encounter and the political consequences this brings about. Drawing from ethnographic research on refugee activism in Germany and transitional justice activism in Uganda, we revisit the respective debates on humanitarian activism, human rights activism, and political activism and argue to reframe the analysis. Instead of looking for the “right” subject position activists should ascribe to the people they engage with, the anthropology of activism should embrace a research approach that looks at the material conditions, in which activists and their subjects find themselves in and the kind of agency they are able to develop within these conditions.